selegiline and dextroamphetamine both increase serotonin levels. Contraindicated. Amphetamines should not be administered during or within 14 days following the use of most MAOIs or drugs with MAO-inhibiting activity
selegiline increases effects of amphetamine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode. Coadministration is contraindicated during or within 14 days following the administration of MAOIs.
albuterol and dextroamphetamine both decrease sedation. Use Caution/Monitor.
albuterol and amphetamine both decrease sedation. Use Caution/Monitor.
amitriptyline and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
amitriptyline and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
amoxapine and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
amoxapine increases effects of amphetamine by unknown mechanism. Use Caution/Monitor.
amoxapine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
amoxapine and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
benzphetamine and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
dextroamphetamine and benzphetamine both decrease sedation. Use Caution/Monitor.
bupropion will increase the level or effect of amphetamine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
dextroamphetamine increases toxicity of bupropion by unspecified interaction mechanism. Use Caution/Monitor. May lower seizure threshold; keep bupropion dose as low as possible.
amphetamine decreases effects of captopril by pharmacodynamic antagonism. Use Caution/Monitor. Amphetamines may decrease the antihypertensive effects of ACE Inhibitors.
chlorpromazine, dextroamphetamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.
chlorpromazine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
clomipramine and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
clomipramine and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
desipramine increases effects of amphetamine by unknown mechanism. Use Caution/Monitor.
desipramine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
desipramine and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
desipramine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
desvenlafaxine will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by up to 50%; no dosage adjustment needed with desvenlafaxine doses
amphetamine and dexfenfluramine both decrease sedation. Use Caution/Monitor.
dexfenfluramine and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
dextroamphetamine and dexfenfluramine both decrease sedation. Use Caution/Monitor.
dexfenfluramine and amphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
dexmethylphenidate and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
dexmethylphenidate and amphetamine both decrease sedation. Use Caution/Monitor.
dobutamine and amphetamine both decrease sedation. Use Caution/Monitor.
dobutamine and amphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
dextroamphetamine and dopamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
amphetamine and dopamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
dopexamine and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
dopexamine and dextroamphetamine both decrease sedation. Use Caution/Monitor.
dosulepin and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
doxepin and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
doxepin and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
duloxetine and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
duloxetine will increase the level or effect of amphetamine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely.
epinephrine and amphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
epinephrine and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
epinephrine racemic and amphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
epinephrine racemic and dextroamphetamine both decrease sedation. Use Caution/Monitor.
dextroamphetamine and fenfluramine both increase serotonin levels. Use Caution/Monitor.
amphetamine and fenfluramine both increase serotonin levels. Use Caution/Monitor.
fluoxetine and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
fluoxetine will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
fluphenazine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
fluphenazine, dextroamphetamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.
formoterol and amphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
formoterol and dextroamphetamine both decrease sedation. Use Caution/Monitor.
hydrocodone, amphetamine. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment.
imipramine increases effects of dextroamphetamine by unknown mechanism. Use Caution/Monitor.
imipramine increases effects of amphetamine by unknown mechanism. Use Caution/Monitor.
imipramine and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
imipramine and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
isoproterenol and amphetamine both decrease sedation. Use Caution/Monitor.
isoproterenol and amphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
levalbuterol and amphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
levalbuterol and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
amphetamine and lisdexamfetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
amphetamine and lisdexamfetamine both decrease sedation. Use Caution/Monitor.
lofepramine increases effects of amphetamine by unknown mechanism. Use Caution/Monitor.
lofepramine and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
lofepramine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lofepramine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
maprotiline and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
maprotiline increases effects of dextroamphetamine by unknown mechanism. Use Caution/Monitor.
maprotiline increases effects of amphetamine by unknown mechanism. Use Caution/Monitor.
maprotiline and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
meperidine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
meperidine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
metaproterenol and dextroamphetamine both decrease sedation. Use Caution/Monitor.
metaproterenol and amphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
amphetamine and methamphetamine both decrease sedation. Use Caution/Monitor.
dextroamphetamine and methamphetamine both decrease sedation. Use Caution/Monitor.
amphetamine and methylenedioxymethamphetamine both decrease sedation. Use Caution/Monitor.
dextroamphetamine and methylenedioxymethamphetamine both decrease sedation. Use Caution/Monitor.
dextroamphetamine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Risk of acute hypertensive episode.
amphetamine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Risk of acute hypertensive episode.
mianserin and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
dextroamphetamine and midodrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
amphetamine and midodrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
amphetamine and mirtazapine both increase serotonin levels. Use Caution/Monitor.
mirtazapine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
morphine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
dextroamphetamine and morphine both increase serotonin levels. Use Caution/Monitor.
norepinephrine and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
norepinephrine and dextroamphetamine both decrease sedation. Use Caution/Monitor.
nortriptyline increases effects of amphetamine by unknown mechanism. Use Caution/Monitor.
nortriptyline and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
nortriptyline increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
nortriptyline increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
amphetamine and pentazocine both increase serotonin levels. Use Caution/Monitor.
pentazocine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
perphenazine, amphetamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.
perphenazine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
dextroamphetamine and phendimetrazine both decrease sedation. Use Caution/Monitor.
amphetamine and phendimetrazine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
dextroamphetamine and phentermine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
amphetamine and phentermine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
amphetamine and phenylephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
amphetamine and phenylephrine both decrease sedation. Use Caution/Monitor.
amphetamine and phenylephrine PO both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
amphetamine and phenylephrine PO both decrease sedation. Use Caution/Monitor.
pirbuterol and dextroamphetamine both decrease sedation. Use Caution/Monitor.
pirbuterol and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
prochlorperazine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
prochlorperazine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
promethazine, amphetamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.
promethazine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
protriptyline and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
protriptyline increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
protriptyline increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
protriptyline and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
amphetamine and pseudoephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
serdexmethylphenidate/dexmethylphenidate and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
serdexmethylphenidate/dexmethylphenidate and dextroamphetamine both decrease sedation. Use Caution/Monitor.
terbutaline and amphetamine both decrease sedation. Use Caution/Monitor.
terbutaline and dextroamphetamine both decrease sedation. Use Caution/Monitor.
tramadol increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
tramadol increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
trazodone increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
trazodone increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
trazodone and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
trazodone increases effects of dextroamphetamine by unknown mechanism. Use Caution/Monitor.
trifluoperazine, dextroamphetamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.
trifluoperazine, amphetamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.
trimipramine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
trimipramine and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
trimipramine increases effects of dextroamphetamine by unknown mechanism. Use Caution/Monitor.
trimipramine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
venlafaxine and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
venlafaxine will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely.
dextroamphetamine and xylometazoline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
amphetamine and xylometazoline both decrease sedation. Use Caution/Monitor.
amphetamine and yohimbine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
amphetamine and yohimbine both decrease sedation. Use Caution/Monitor.
acetazolamide will increase the level or effect of amphetamine by passive renal tubular reabsorption - basic urine. Use Caution/Monitor. Minor (2) acetazolamide increases levels of dextroamphetamine by passive renal tubular reabsorption due to increased pH. Minor/Significance Unknown.
albuterol and dextroamphetamine both decrease sedation. Use Caution/Monitor.
albuterol and amphetamine both decrease sedation. Use Caution/Monitor.
alfentanil increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (2) amphetamine increases effects of alfentanil by unspecified interaction mechanism. Minor/Significance Unknown.
amitriptyline increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
amitriptyline increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
amitriptyline increases effects of dextroamphetamine by unknown mechanism. Use Caution/Monitor.
amitriptyline increases effects of amphetamine by unknown mechanism. Use Caution/Monitor.
amitriptyline and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely. Serious - Use Alternative (2) amitriptyline, dextroamphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
amoxapine and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
amoxapine increases effects of amphetamine by unknown mechanism. Use Caution/Monitor.
amoxapine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
amoxapine and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
amoxapine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Serious - Use Alternative (2) amoxapine, dextroamphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
arformoterol and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
arformoterol and amphetamine both decrease sedation. Use Caution/Monitor.
belladonna and opium increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (2) dextroamphetamine increases effects of belladonna and opium by unspecified interaction mechanism. Minor/Significance Unknown.
benzphetamine and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
dextroamphetamine and benzphetamine both decrease sedation. Use Caution/Monitor.
buprenorphine buccal increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (2) dextroamphetamine increases effects of buprenorphine buccal by unspecified interaction mechanism. Minor/Significance Unknown.
bupropion will increase the level or effect of amphetamine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
dextroamphetamine increases toxicity of bupropion by unspecified interaction mechanism. Use Caution/Monitor. May lower seizure threshold; keep bupropion dose as low as possible.
butorphanol increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (2) dextroamphetamine increases effects of butorphanol by unspecified interaction mechanism. Minor/Significance Unknown.
amphetamine decreases effects of captopril by pharmacodynamic antagonism. Use Caution/Monitor. Amphetamines may decrease the antihypertensive effects of ACE Inhibitors.
chlorpromazine, dextroamphetamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.
chlorpromazine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
clomipramine increases effects of dextroamphetamine by unknown mechanism. Use Caution/Monitor.
clomipramine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
clomipramine increases effects of amphetamine by unknown mechanism. Use Caution/Monitor.
clomipramine and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
clomipramine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Serious - Use Alternative (2) clomipramine, dextroamphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
codeine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (2) amphetamine increases effects of codeine by unspecified interaction mechanism. Minor/Significance Unknown.
amphetamine increases and cyproheptadine decreases serotonin levels. Effect of interaction is not clear, use caution. Use Caution/Monitor.
desipramine increases effects of amphetamine by unknown mechanism. Use Caution/Monitor.
desipramine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
desipramine and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
desipramine and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
desipramine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Serious - Use Alternative (2) desipramine, dextroamphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
amphetamine and dexfenfluramine both decrease sedation. Use Caution/Monitor.
dexfenfluramine and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
dextroamphetamine and dexfenfluramine both decrease sedation. Use Caution/Monitor.
dexfenfluramine and amphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
dexmethylphenidate and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
dexmethylphenidate and amphetamine both decrease sedation. Use Caution/Monitor.
dextromoramide increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (2) amphetamine increases effects of dextromoramide by unspecified interaction mechanism. Minor/Significance Unknown.
diamorphine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (2) dextroamphetamine increases effects of diamorphine by unspecified interaction mechanism. Minor/Significance Unknown.
amphetamine and diethylpropion both decrease sedation. Use Caution/Monitor.
dextroamphetamine and diethylpropion both decrease sedation. Use Caution/Monitor.
difenoxin hcl increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (2) amphetamine increases effects of difenoxin hcl by unspecified interaction mechanism. Minor/Significance Unknown.
amphetamine and dihydroergotamine both increase serotonin levels. Use Caution/Monitor. Serious - Use Alternative (2) dihydroergotamine, dextroamphetamine. Mechanism: pharmacodynamic synergism. Contraindicated. Additive vasospasm; risk of hypertension.
amphetamine and dihydroergotamine intranasal both increase serotonin levels. Use Caution/Monitor. Serious - Use Alternative (2) dihydroergotamine intranasal, amphetamine. Mechanism: pharmacodynamic synergism. Contraindicated. Additive vasospasm; risk of hypertension.
diphenhydramine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (2) diphenhydramine will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
diphenoxylate hcl increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (2) amphetamine increases effects of diphenoxylate hcl by unspecified interaction mechanism. Minor/Significance Unknown.
dipipanone increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (2) dextroamphetamine increases effects of dipipanone by unspecified interaction mechanism. Minor/Significance Unknown.
dobutamine and amphetamine both decrease sedation. Use Caution/Monitor.
dobutamine and amphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
dextroamphetamine and dopamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
amphetamine and dopamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
dopexamine and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
dopexamine and dextroamphetamine both decrease sedation. Use Caution/Monitor.
dosulepin and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
doxepin increases effects of amphetamine by unknown mechanism. Use Caution/Monitor.
doxepin and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
doxepin and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
doxepin increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
doxepin increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Serious - Use Alternative (2) doxepin, dextroamphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
duloxetine and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
duloxetine will increase the level or effect of amphetamine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely.
ephedrine and amphetamine both decrease sedation. Use Caution/Monitor.
ephedrine and amphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
epinephrine and amphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
epinephrine and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
epinephrine racemic and amphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
epinephrine racemic and dextroamphetamine both decrease sedation. Use Caution/Monitor.
amphetamine and ergotamine both increase serotonin levels. Use Caution/Monitor. Serious - Use Alternative (2) ergotamine, amphetamine. Mechanism: pharmacodynamic synergism. Contraindicated. Additive vasospasm; risk of hypertension.
dextroamphetamine and fenfluramine both decrease sedation. Use Caution/Monitor.
dextroamphetamine and fenfluramine both increase serotonin levels. Use Caution/Monitor.
amphetamine and fenfluramine both increase serotonin levels. Use Caution/Monitor.
amphetamine and fenfluramine both decrease sedation. Use Caution/Monitor.
fluoxetine and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
fluoxetine will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
fluphenazine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
fluphenazine, dextroamphetamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.
formoterol and amphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
formoterol and dextroamphetamine both decrease sedation. Use Caution/Monitor.
haloperidol increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (2) haloperidol will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
hydralazine, amphetamine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of hypertension.
hydrocodone increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
hydromorphone increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (2) dextroamphetamine increases effects of hydromorphone by unspecified interaction mechanism. Minor/Significance Unknown.
imipramine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
imipramine increases effects of amphetamine by unknown mechanism. Use Caution/Monitor.
imipramine and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
imipramine and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
imipramine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Serious - Use Alternative (2) imipramine, dextroamphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
isocarboxazid increases effects of dextroamphetamine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode. Serious - Use Alternative (2) isocarboxazid and dextroamphetamine both increase serotonin levels. Avoid or Use Alternate Drug.
isoproterenol and amphetamine both decrease sedation. Use Caution/Monitor.
isoproterenol and amphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
levalbuterol and amphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
levalbuterol and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
levorphanol increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (2) dextroamphetamine increases effects of levorphanol by unspecified interaction mechanism. Minor/Significance Unknown.
linezolid increases effects of dextroamphetamine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode. Serious - Use Alternative (2) linezolid and amphetamine both increase serotonin levels. Avoid or Use Alternate Drug. Linezolid may increase serotonin as a result of MAO-A inhibition. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first.
amphetamine and lisdexamfetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
amphetamine and lisdexamfetamine both decrease sedation. Use Caution/Monitor.
lofepramine increases effects of amphetamine by unknown mechanism. Use Caution/Monitor.
lofepramine and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
lofepramine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lofepramine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lofepramine and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely. Serious - Use Alternative (2) lofepramine, dextroamphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
maprotiline increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
maprotiline increases effects of dextroamphetamine by unknown mechanism. Use Caution/Monitor.
maprotiline increases effects of amphetamine by unknown mechanism. Use Caution/Monitor.
maprotiline and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
maprotiline increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Serious - Use Alternative (2) maprotiline, dextroamphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
marijuana increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (2) marijuana will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
meperidine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
meperidine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
amphetamine and meperidine both increase serotonin levels. Modify Therapy/Monitor Closely. Minor (2) dextroamphetamine increases effects of meperidine by unspecified interaction mechanism. Minor/Significance Unknown.
metaproterenol and amphetamine both decrease sedation. Use Caution/Monitor.
metaproterenol and amphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
methadone increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (2) dextroamphetamine increases effects of methadone by unspecified interaction mechanism. Minor/Significance Unknown.
amphetamine and methamphetamine both decrease sedation. Use Caution/Monitor.
dextroamphetamine and methamphetamine both decrease sedation. Use Caution/Monitor.
amphetamine and methylenedioxymethamphetamine both decrease sedation. Use Caution/Monitor.
dextroamphetamine and methylenedioxymethamphetamine both decrease sedation. Use Caution/Monitor.
dextroamphetamine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Risk of acute hypertensive episode.
amphetamine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Risk of acute hypertensive episode.
mianserin and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
dextroamphetamine and midodrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
amphetamine and midodrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
amphetamine and mirtazapine both increase serotonin levels. Use Caution/Monitor.
mirtazapine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
morphine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
dextroamphetamine and morphine both increase serotonin levels. Use Caution/Monitor.
amphetamine and morphine both increase serotonin levels. Use Caution/Monitor. Minor (2) dextroamphetamine increases effects of morphine by unspecified interaction mechanism. Minor/Significance Unknown.
nalbuphine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (2) dextroamphetamine increases effects of nalbuphine by unspecified interaction mechanism. Minor/Significance Unknown.
norepinephrine and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
norepinephrine and dextroamphetamine both decrease sedation. Use Caution/Monitor.
nortriptyline increases effects of amphetamine by unknown mechanism. Use Caution/Monitor.
nortriptyline and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
nortriptyline increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
nortriptyline increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
nortriptyline increases effects of dextroamphetamine by unknown mechanism. Use Caution/Monitor. Serious - Use Alternative (2) nortriptyline, dextroamphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
opium tincture increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (2) dextroamphetamine increases effects of opium tincture by unspecified interaction mechanism. Minor/Significance Unknown.
oxycodone increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (2) dextroamphetamine increases effects of oxycodone by unspecified interaction mechanism. Minor/Significance Unknown.
oxymorphone increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (2) amphetamine increases effects of oxymorphone by unspecified interaction mechanism. Minor/Significance Unknown.
papaveretum increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (2) amphetamine increases effects of papaveretum by unspecified interaction mechanism. Minor/Significance Unknown.
paroxetine and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
paroxetine will increase the level or effect of amphetamine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
amphetamine and pentazocine both increase serotonin levels. Use Caution/Monitor.
pentazocine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
dextroamphetamine and pentazocine both increase serotonin levels. Use Caution/Monitor. Minor (2) amphetamine increases effects of pentazocine by unspecified interaction mechanism. Minor/Significance Unknown.
perphenazine, amphetamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.
perphenazine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
perphenazine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (2) perphenazine will increase the level or effect of amphetamine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
dextroamphetamine and phendimetrazine both decrease sedation. Use Caution/Monitor.
amphetamine and phendimetrazine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
phenelzine increases effects of dextroamphetamine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode. Serious - Use Alternative (2) phenelzine and dextroamphetamine both increase serotonin levels. Avoid or Use Alternate Drug.
dextroamphetamine and phentermine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
amphetamine and phentermine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
amphetamine and phenylephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
amphetamine and phenylephrine both decrease sedation. Use Caution/Monitor.
amphetamine and phenylephrine PO both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
amphetamine and phenylephrine PO both decrease sedation. Use Caution/Monitor.
pirbuterol and dextroamphetamine both decrease sedation. Use Caution/Monitor.
pirbuterol and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
procarbazine increases effects of dextroamphetamine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode. Serious - Use Alternative (2) procarbazine and amphetamine both increase serotonin levels. Avoid or Use Alternate Drug.
prochlorperazine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
prochlorperazine, amphetamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.
promethazine, amphetamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.
promethazine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
dextroamphetamine and propylhexedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
amphetamine and propylhexedrine both decrease sedation. Use Caution/Monitor.
protriptyline and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
protriptyline increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
protriptyline increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
protriptyline and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
protriptyline increases effects of dextroamphetamine by unknown mechanism. Use Caution/Monitor. Serious - Use Alternative (2) protriptyline, dextroamphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
amphetamine and pseudoephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
salmeterol and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
salmeterol and amphetamine both decrease sedation. Use Caution/Monitor.
selegiline and dextroamphetamine both increase serotonin levels. Contraindicated. Amphetamines should not be administered during or within 14 days following the use of most MAOIs or drugs with MAO-inhibiting activity
selegiline increases effects of amphetamine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode. Coadministration is contraindicated during or within 14 days following the administration of MAOIs.
selegiline transdermal increases effects of amphetamine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode. Monitor Closely (2) selegiline transdermal and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
serdexmethylphenidate/dexmethylphenidate and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
serdexmethylphenidate/dexmethylphenidate and dextroamphetamine both decrease sedation. Use Caution/Monitor.
sertraline and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
sertraline will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
sufentanil increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (2) amphetamine increases effects of sufentanil by unspecified interaction mechanism. Minor/Significance Unknown.
tapentadol increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (2) dextroamphetamine increases effects of tapentadol by unspecified interaction mechanism. Minor/Significance Unknown.
terbutaline and amphetamine both decrease sedation. Use Caution/Monitor.
terbutaline and dextroamphetamine both decrease sedation. Use Caution/Monitor.
thioridazine, dextroamphetamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.
thioridazine, amphetamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.
thioridazine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (2) thioridazine will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
tramadol increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
tramadol increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
amphetamine and tramadol both increase serotonin levels. Use Caution/Monitor. Minor (2) amphetamine increases effects of tramadol by unspecified interaction mechanism. Minor/Significance Unknown.
tranylcypromine increases effects of amphetamine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode. Serious - Use Alternative (2) tranylcypromine and dextroamphetamine both increase serotonin levels. Avoid or Use Alternate Drug.
trazodone increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
trazodone and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
trazodone increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
trazodone increases effects of dextroamphetamine by unknown mechanism. Use Caution/Monitor.
trazodone increases effects of amphetamine by unknown mechanism. Use Caution/Monitor. Serious - Use Alternative (2) trazodone, dextroamphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
trifluoperazine, dextroamphetamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.
trifluoperazine, amphetamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.
trimipramine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
trimipramine and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
trimipramine increases effects of dextroamphetamine by unknown mechanism. Use Caution/Monitor.
trimipramine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
trimipramine increases effects of amphetamine by unknown mechanism. Use Caution/Monitor. Serious - Use Alternative (2) trimipramine, dextroamphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
venlafaxine and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.
venlafaxine will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely.
dextroamphetamine and xylometazoline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
amphetamine and xylometazoline both decrease sedation. Use Caution/Monitor.
amphetamine and yohimbine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
amphetamine and yohimbine both decrease sedation. Use Caution/Monitor.